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Biosafety
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Useful information and guidelines

Access resources related to biosafety and biosecurity.

Last updated 15 April 2025

On this page

Facility Registration and Certification
Genetically Modified Organisms
Healthcare Application Licensing Portal (HALP) Biosafety Module
Importation, Transhipment, Transportation and Packaging
International Guidelines/Resources
Protected Place and Physical Security
Risk Assessment

Facility Registration and Certification

  1. Biorisk Management Standard for Large-Scale Work With Biological Agents

  2. Guidance Document for Development of Facility Administrative Oversight Plan

  3. List of MOH-Approved Facility Certification Body

  4. MOH-BSL3 Laboratory Certification Checklist

  5. National Biosafety Standards for Maximum Containment Facilities

  6. SS696:2023 Specification for High Containment (Biosafety Level 3) Facility

Genetically Modified Organisms

  1. Multi-Agency Joint Circular on Guidelines for Research, Release, and Importation of GMOs

Healthcare Application Licensing Portal (HALP) Biosafety Module

  1. Healthcare Application Licensing Portal Biosafety (HALP-Biosafety) Training Slides

  2. Facility User Guide Part 1

  3. Facility User Guide Part 2.1

  4. Facility User Guide Part 2.2

  5. Facility User Guide Part 3

  6. Facility User Guide Part 4

Importation, Transhipment, Transportation and Packaging

  1. Guidelines on the Import and Transhipment of Biological Agents and Toxins

  2. IATA Guidance Document for Transport of Infectious Substances

  3. Import Advisory for Importers, Freight Forwarders and End-users of Biological Agents and Toxins

  4. List of Biological Agents & Toxins

  5. WHO Guidance on Regulations for the Transport of Infectious Substances

International Guidelines/Resources

  1. Canada Biosafety Guidelines

  2. CDC and NIH: Biosafety in Microbiological and Biomedical Laboratories 6th Ed

  3. National Institutes of Health: Biosafety Level 3-Laboratory Certification Requirements

  4. WHO Laboratory Biosafety Manual 3rd Edition

  5. WHO Laboratory Biosafety Manual 4th Edition

Protected Place and Physical Security

  1. Application for Gazette or De-Gazette as a protected place and Personnel Vetting [PDF, 222 KB]

  2. Circular on Physical Security for Facilities Handling First Schedule Part I, Third Schedule and Fourth Schedule biological agents under the Biological Agents and Toxins Act [PDF, 118 KB]

  3. Annex A: Guidelines for Required Security Measures at Facilities Storing Tier 1 Security Sensitive Materials/Hazardous Materials

Note: Facilities are advised to approach MOH Biosafety Branch for the inspection checklist.

Risk Assessment

  1. Risk Assessment Guidelines [PDF, 90 KB]

  2. Risk Assessment Sample Template[XLSX, 48 KB]